The holy seed. Compare Isaiah 6:13. The "seed of Israel," however much it polluted itself by transgressions, was still "holy" by profession, by call, by obligation, by prophetic announcement. They were "a kingdom of priests, a holy nation" (Exodus 19:6); bound to be "separated from all the people that were on the face of the earth" (Exodus 33:16), and to keep themselves a "peculiar people."
When they mingled themselves with the people of the lands, they not only broke a positive command (Deuteronomy 7:3), but did their best to frustrate God's entire purpose in respect of them, and to render all that he had done for them of no effect.
The hand of the princes and rulers hath been chief in the trespass. "Princes and rulers" are here opposed to people of the middle and lower ranks. The upper classes, whether clerical or lay, had been the chief offenders (see Ezra 10:18); and compare the similar defection of Jews of the upper classes in Nehemiah's time (Nehemiah 6:17, Nehemiah 6:18; Nehemiah 13:4, Nehemiah 13:28).